Aims and Scope

The Open Neurology Journal is an Open Access journal, which publishes high quality research articles, reviews/mini-reviews, letters and guest edited single topic issues in all important areas of neurology and neurological disorders. The scope of the journal includes:

  • Neurological progress
  • Neurological and psychiatric therapies
  • Stem cell applications
  • Biomathematical models
  • Neuroradiology
  • Molecular neuroscience
  • Neuropharmacology
  • Neurochemistry
The Open Neurology Journal, a peer-reviewed journal, is an important and reliable source of current information on important developments in the field. Emphasis is placed on publishing quality papers, making them freely available to researchers worldwide.

Recent Articles

Editor's Choice

Cancer Risk in Elderly Korean Patients with Neurodegenerative Disease and its relation to Type 2 Diabetes

Hee-Cheol Kim, Ji-Hun Kim, Ho-Jun Lee, Yang-Tae Kim, Byeong-Churl Jang


Some studies suggest that neurodegenerative diseases (NDs), cancer, and type 2 diabetes (T2D) are all related to protein misfolding and may be linked. This study aimed to determine whether these diseases are associated with each other.


The aim of the study was to investigate the difference in cancer incidence according to the presence or absence of T2D in the ND group and the control group during the 10-year follow-up period.


A population-based 10-year follow-up study was conducted using the Korean National Health Insurance Service Database between 2002 and 2015. The study population included the ND group (n = 9,292) and the control group (n = 46,742), who were aged 60 to 84 years. Cox proportional hazards regression was used to estimate multivariable-adjusted hazard ratios (HRs) for cancer.


ND and/or T2D were newly diagnosed in both groups during the follow-up period. The newly diagnosed ND cases before cancer onset were 2,412 (26.0%) and 15,435 (33.0%) in the ND and control groups, respectively (p < 0.01). The newly diagnosed T2D cases were 4,691 (50.5%) and 25,695 (55.0%) in the ND and control groups, respectively (p < 0.01). At the end of the observation period, the number of cancer patients was 2,040 (22.0%) and 8,628 (18.5%) in the ND and control groups, respectively (p < 0.01). The ND group was associated with an increased risk of cancer (HR = 1.25). In both groups, newly diagnosed ND and T2D showed an additive effect on cancer incidence during the follow-up period.


This study showed that cancer incidence was positively associated with ND and T2D. These results show that ND, cancer, and T2D are related. More replication studies are needed to address the association between ND, cancer, and T2D.

July 17, 2023

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