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Chronic Pain And Levodopa Therapy in Parkinson’s Disease Patients
Marcelo Rezende Young Blood2
Camila Medyk2
Matheus Gomes Ferreira3
Marcelo Machado Ferro4
Hélio Afonso Ghizoni Teive1 , 3
Authors Info & Affiliations
Abstract
Background:
Pain is a frequent non-motor symptom in patients with Parkinson’s disease (PD) and appears to be related to low levels of dopamine. This study describes the characteristics of chronic pain in a group of PD patients undergoing levodopa therapy.
Methods:
This was a cross-sectional study. The pain was assessed in 21 selected PD patients with chronic pain using several scales and instruments. Changes in pain response from levodopa use (wearing-off phenomenon) were monitored.
Results:
The most prevalent type of pain was nociceptive (71.4%), musculoskeletal and dystonic, but neuropathic pain accounted for the highest pain score according to the Parkinson’s Disease Pain Classification System (45.5±30.08). Patients with neuropathic, nociplastic, or nociceptive pain upon wearing-off were those who responded to levodopa (p=0.999). According to the McGill questionnaire, patients with pain upon wearing-off had higher scores in the affective/motivational dimension (p=0.022).
Conclusion:
Using a new pain classification and scoring tool, this study corroborates a good response to levodopa in PD-related pain.
