RESEARCH ARTICLE


Leukocyte Count and Neutrophil-To-Lymphocyte Ratio as Simple Hematologic Predictors of Stroke Severity and Functional Outcome in Acute Ischemic Stroke Patients



Rizaldy Taslim Pinzon1, 2, *, Vanessa Veronica1
1 Duta Wacana Christian University School of Medicine, Yogyakarta, Indonesia
2 Department of Neurology, Bethesda Hospital, Yogyakarta, Indonesia


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Creative Commons License
© 2022 Pinzon and Veronica

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at the Duta Wacana Christian University School of Medicine, Yogyakarta, Indonesia. Wahidin Sudirohusodo st. 5-25, Yogyakarta, Indonesia; E-mail: drpinzon17@gmail.com


Abstract

Background:

It has long been recognized that inflammation plays a critical role in the pathogenesis of ischemic stroke. However, whether leukocyte count and neutrophil-to-lymphocyte ratio are related to stroke severity and functional outcome is uncertain.

Objective:

This clinical study aimed to evaluate the association of leukocyte count and neutrophil-to-lymphocyte ratio with stroke severity and functional outcome in acute ischemic stroke patients.

Methods:

This hospital-based, retrospective observational study included 112 subjects with acute ischemic stroke. All subjects had their demographic, clinical, and laboratory data obtained. The leukocyte count and neutrophil-to-lymphocyte ratio were evaluated by stroke severity on admission and 3-month functional outcome. The severity of stroke at admission was measured using the National Institutes of Health Stroke Scale (NIHSS), whereas the Barthel Index was used to measure 3-month functional outcome (BI). We conducted a regression analysis, adjusting for any confounding variables.

Results:

Higher leukocyte count was significantly associated with increased risk of stroke severity (odds ratio [OR] 1.391, 95% confidence intervals [CI], 1.121-1.725, p: 0.003) and unfavorable functional outcome (OR 1.434, 95% CI, 1.068-1.925, p: 0.017). Higher neutrophil-to-lymphocyte ratio was not significantly associated with increased risk of stroke severity (OR 1.181, 95% CI, 0.947-1.474, p: 0.140) and unfavorable functional outcome (OR 1.246, 95% CI, 0.905-1.716, p: 0.177).

Conclusion:

Our study indicates that leukocyte count is an independent predictor of stroke severity on admission and unfavorable functional outcome.

Keywords: Ischemic stroke, Inflammation, Leukocyte count, Neutrophil-to-lymphocyte ratio, Prognosis, Stroke.