RESEARCH ARTICLE

Dilative Arteriopathy and Leucencephalopathy as Manifestations of a Neurometabolic Disease

The Open Neurology Journal 26 June 2015 RESEARCH ARTICLE DOI: 10.2174/1874205X01509010028

Abstract

Background:

Dilative arteriopathy plus leucencephalopathy as a manifestation of a mitochondrial disorder (MID) is rare.

Case report:

In a 70yo Caucasian female, height 160cm, weight 62kg, with mild right-sided hemiparesis due to subacute ischemic stroke in the posterior leg of the left internal capsule, a megadolichobasilar artery and marked leucencephalopathy and gliosis of the pons were detected. In addition, microbleeds in a peripheral distribution at the cortical/subcortical border were noted. After the exclusion of various differentials, which could have explained her abnormalities, a MID was suspected.

Conclusions:

Dilative arteriopathy of the intra-cerebral arteries, in association with recurrent stroke and supra- and infratentorial leucencephalopathy, but the absence of neurofibromatosis or increased low-density lipoprotein values, is most likely attributable to a non-syndromic MID.

Keywords: Mitochondrial disorder, genetics, dilative arteriopathy, megadolichobasilar artery, arteriopathy, stroke.
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