Migraine and Genetic Polymorphisms: An Overview



Vincenzo Pizza1, Anella Agresta1, Antonio Agresta1, Eros Lamaida1, Norman Lamaida1, Francesco Infante2, Anna Capasso3, *
1 Neurophysiopathology Service, S. Luca Hospital, Vallo della Lucania (SA), Italy
2 Biochemical Laboratory, S. Luca Hospital, Vallo della Lucania (SA), Italy
3 Department of Pharmaceutical and Biomedical Sciences, University of Salerno, Italy


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© Finsterer and Stöllberger; Licensee Bentham Open.

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

* Address correspondence to this author at the Department of Pharmaceutical and Biomedical Sciences, University of Salerno, Italy; Tel: +39 089 969744; Fax: +39 089 966262; E-mail: annacap@unisa.it


Abstract

The relationship between genetic polymorphisms and migraine as a cause of an increased risk of thrombotic disorders development is still debated

In this respect, factor V Leiden, factor V (H1299R), prothrombin G20210A, factor XIII (V34L), β-fibrinogen, MTHFR (C677T), MTHFR (A1298C), APO E, PAI-1, HPA-1 and ACE I/D seem to play a determinant role in vascular diseases related to migraine.

The present review analyzes both the incidence of the above genetic vascular mutations in migraineurs and the most re-cent developments related to genetic polymorphisms and migraine.

Keywords:: Genetic Polymorphisms, Migraine, Thrombosis, Vascular Disease.