Migraine and Genetic Polymorphisms: An Overview
Vincenzo Pizza1, Anella Agresta1, Antonio Agresta1, Eros Lamaida1, Norman Lamaida1, Francesco Infante2, Anna Capasso3, *
Identifiers and Pagination:Year: 2012
First Page: 65
Last Page: 70
Publisher ID: TONEUJ-6-65
Article History:Received Date: 28/4/2012
Revision Received Date: 22/6/2012
Acceptance Date: 02/7/2012
Electronic publication date: 17/8/2012
Collection year: 2012
open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
The relationship between genetic polymorphisms and migraine as a cause of an increased risk of thrombotic disorders development is still debated
In this respect, factor V Leiden, factor V (H1299R), prothrombin G20210A, factor XIII (V34L), β-fibrinogen, MTHFR (C677T), MTHFR (A1298C), APO E, PAI-1, HPA-1 and ACE I/D seem to play a determinant role in vascular diseases related to migraine.
The present review analyzes both the incidence of the above genetic vascular mutations in migraineurs and the most re-cent developments related to genetic polymorphisms and migraine.