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RESEARCH ARTICLE

Migraine and Genetic Polymorphisms: An Overview

Vincenzo Pizza1 Anella Agresta1 Antonio Agresta1 Eros Lamaida1 Norman Lamaida1 Francesco Infante2 Anna Capasso3 , * Open Modal Authors Info & Affiliations
The Open Neurology Journal • 17 Aug 2012 • RESEARCH ARTICLE • DOI: 10.2174/1874205X01206010065

Abstract

The relationship between genetic polymorphisms and migraine as a cause of an increased risk of thrombotic disorders development is still debated

In this respect, factor V Leiden, factor V (H1299R), prothrombin G20210A, factor XIII (V34L), β-fibrinogen, MTHFR (C677T), MTHFR (A1298C), APO E, PAI-1, HPA-1 and ACE I/D seem to play a determinant role in vascular diseases related to migraine.

The present review analyzes both the incidence of the above genetic vascular mutations in migraineurs and the most re-cent developments related to genetic polymorphisms and migraine.

Keywords:: Genetic Polymorphisms, Migraine, Thrombosis, Vascular Disease.
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