A Multicentre Database for Normative Brainstem Auditory Evoked Potentials (BAEPs) in Children: Methodology for Data Collection and Evaluation



Vidmer Scaioli*, 1, Mario Brinciotti2, Matteo Di Capua3, Silvia Lori4, Augusta Janes5, Giancarlo Pastorino6, Cinzia Peruzzi7, Paola Sergi6, Agnese Suppiej8
1 Fondazione IRCCS Istituto Nazionale Neurologico C. Besta, Milan;
2 Università La Sapienza, Rome;
3 Ospedale Bambin Gesù, Rome;
4 Clinica Neurologica Ospedale Pediatrico A.Mayer, Università di Firenze, Florence;
5 Neonatologia, Ospedale Civile, Udine;
6 Istituti Clinici di Perfezionamento, Milan;
7 UO Neuropsichiatria, Ospedale Civile, Novara;
8 Dipartimento Pediatria, Università di Padova, Padua, Italy;


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© Scaioli et al.; Licensee Bentham Open.

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

* Address correspondence to this author at the Department of Pharmaceutical Sciences, University of Salerno, Italy; E-mail:annacap@unisa.it


Abstract

Background:

The influence of physiological and methodological factors on recordings of brainstem auditory evoked potentials (BAEPs) is greater in children than in adults.

Objective:

To collect and evaluate BAEP data in normal children, and measure intra- and inter-laboratory variability.

Methods:

Seven hundred and fifty unselected BAEP recordings were collected and evaluated from children ranging from neonates to 14-year-olds by eight laboratories in Italy.

Results:

In newborns, three laboratories showed satisfactory concordance; wave I was more broadly distributed than wave V and IPL I-V. The evaluation of pooled BAEP data from the older children showed that laboratories with age-matched data gave overlapping results; those with unmatched-age data differed significantly. The sound intensities of the laboratories did not significantly affect absolute BAEP latencies or IPLs. Females had shorter latencies than males; the difference was not significant. A single exponential regression model was an adequate but not the best predictor of normal data.

Conclusions:

The pooled data were consistent with the physiological maturation of the brainstem acoustic pathway. The BAEPs was reliably normalised using the natural logarithm of age. The differences between Centres were related to sample size, measurement accuracy, and inclusion and selection criteria.

Significance:

The creation of multicentre common database from an unmatched data collection is feasible and reliable enough for clinical diagnosis and multicentre clinical research.

Key Words: BAEPs, maturation, normative data, children, brainstem, auditory evoked potentials.