Migraine: An Overview

Salvatore Salomone1, Filippo Caraci2, Anna Capasso3, *
1 Department of Pharmacology University of Catania;
2 Department of Pharmaceutical Sciences, University of Catania;
3 Department of Pharmaceutical Sciences, University of Salerno, Italy

Article Metrics

CrossRef Citations:
Total Statistics:

Full-Text HTML Views: 2670
Abstract HTML Views: 1719
PDF Downloads: 563
Total Views/Downloads: 4952
Unique Statistics:

Full-Text HTML Views: 1170
Abstract HTML Views: 1049
PDF Downloads: 382
Total Views/Downloads: 2601

Creative Commons License
© Salomone et al.; Licensee Bentham Open.

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

* *Address correspondence to this author at the Department of Pharmaceutical Sciences, University of Salerno, Italy;


The pathophysiology of migraine is not completely understood and continues to be investigated. The complexity of interactions taking place in the sensory neuronal network with the mediation of all different neurotransmitters involved ives the measure of the extreme difficulty connected with the knowledge of migraine pathogenesis and in particular of its cardinal sign. Neuronal components are relevant in migraine pathophysiology: there could be a generalized interictal abnormal excitability of the cerebral cortex in migraine, possibly favoring the occurrence of spreading depression with consequent activation of the trigeminal system. Many theories have been formulated in these last sixty years about the pathogenesis of migraine and other forms of primary headache, but the problem is still far to be fully clarified. The present review is focused on the description of different theories on the migraine pathogenesis.