Investigation Between the S377G3 GATA-4 Polymorphism and Migraine

Chikhani Sherin§, 1, Fernandez Francesca§, 1, Poetter Karl2, Toohey Brendan2, Harvey Ron3, Griffiths Lyn*, 1
1 Genomics Research Centre, Griffith University, Gold Coast, Queensland, Australia
2 Genera Biosystems Pty Ltd, Bundoora, Victoria, Australia
3 The Victor Cardiac Research Institute, St. Vincents Hospital, Darlinghurst, Australia

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© Sherin et al.; Licensee Bentham Open.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestrictive use, distribution, and reproduction in any medium, provided the original work is properly cited.

* Address correspondence to this author at the Genomics Research Centre, School of Medical Science, Griffith University, PMB 50, Gold Coast Mail Centre, Queensland, 9726 Australia; Tel: 61 7 5552 8664; Fax: 61 7 5594 8908; E-mail:
§ These authors contributed equally to this work.


Migraine is a common and painful neurological disorder, with genetic and environmental components. Several conditions have been shown to be comorbid with migraine, notably a cardiac malformation affecting the interatrial septum and leading to patent foramen ovale (PFO). Mutations in the development regulatory gene GATA-4, located on human chromosome 8p23.1-p22, have been found to be responsible for some cases of congenital heart defects including PFO. To determine whether the GATA-4 gene is involved in migraine, the present study performed an association analysis of a common GATA-4 variant that results in a change of amino acid (S377G), in a large case/control population (275 unrelated Caucasian migraineurs versus 275 control individuals). The results showed that there was no significant association for this polymorphism between migraine and controls (χ² = 0.84, P = 0.66). Thus it appears that the GATA-4 (S377G) mutation does not play a significant role in common migraine susceptibility.

Keywords: Migraine, genetic association, GATA 4 polymorphism, Heart disorder.