Investigation Between the S377G3 GATA-4 Polymorphism and Migraine



Chikhani Sherin§, 1, Fernandez Francesca§, 1, Poetter Karl2, Toohey Brendan2, Harvey Ron3, Griffiths Lyn*, 1
1 Genomics Research Centre, Griffith University, Gold Coast, Queensland, Australia
2 Genera Biosystems Pty Ltd, Bundoora, Victoria, Australia
3 The Victor Cardiac Research Institute, St. Vincents Hospital, Darlinghurst, Australia


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© Sherin et al.; Licensee Bentham Open.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.5/), which permits unrestrictive use, distribution, and reproduction in any medium, provided the original work is properly cited.

* Address correspondence to this author at the Genomics Research Centre, School of Medical Science, Griffith University, PMB 50, Gold Coast Mail Centre, Queensland, 9726 Australia; Tel: 61 7 5552 8664; Fax: 61 7 5594 8908; E-mail: l.griffiths@griffith.edu.au
§ These authors contributed equally to this work.


Abstract

Migraine is a common and painful neurological disorder, with genetic and environmental components. Several conditions have been shown to be comorbid with migraine, notably a cardiac malformation affecting the interatrial septum and leading to patent foramen ovale (PFO). Mutations in the development regulatory gene GATA-4, located on human chromosome 8p23.1-p22, have been found to be responsible for some cases of congenital heart defects including PFO. To determine whether the GATA-4 gene is involved in migraine, the present study performed an association analysis of a common GATA-4 variant that results in a change of amino acid (S377G), in a large case/control population (275 unrelated Caucasian migraineurs versus 275 control individuals). The results showed that there was no significant association for this polymorphism between migraine and controls (χ² = 0.84, P = 0.66). Thus it appears that the GATA-4 (S377G) mutation does not play a significant role in common migraine susceptibility.

Keywords: Migraine, genetic association, GATA 4 polymorphism, Heart disorder.