Epidemiology and Clinical Course of Chronic Autoimmune Neuropathies During the SARS-CoV-2 Pandemic in Latvia

Ieva Glāzere1, 2, Marija Luīze Kalniņa3, *, Dmitrijs Rots4, Marija Roddate1, Linda Gailīte2, 4, Nataļja Kurjāne2, 5, Viktorija Ķēniņa2, 6
1 Department of Neurology, Pauls Stradins Clinical University Hospital, Riga, Latvia
2 Department of Biology and Microbiology, Riga Stradins University, Riga, Latvia
3 Department of Neurology and Neurosurgery, Children's Clinical University Hospital, Riga, Latvia
4 Scientific Laboratory of Molecular Genetics, Riga Stradins University, Riga, Latvia
5 Outpatient Service Centre, Pauls Stradins Clinical University Hospital, Riga, Latvia
6 Rare Disease Centre, Riga East Clinical University Hospital, Riga, Latvia

Article Metrics

CrossRef Citations:
Total Statistics:

Full-Text HTML Views: 756
Abstract HTML Views: 658
PDF Downloads: 520
ePub Downloads: 342
Total Views/Downloads: 2276
Unique Statistics:

Full-Text HTML Views: 430
Abstract HTML Views: 270
PDF Downloads: 378
ePub Downloads: 257
Total Views/Downloads: 1335

Creative Commons License
© 2023 Glāzere et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at the Department of Neurology and Neurosurgery, Children's Clinical University Hospital, Riga, Latvia; E-mail:



Chronic autoimmune neuropathies are a group of rare neurological disorders caused by the immune response to autoantigens in the peripheral nervous system.


This study aimed to report epidemiological data in Latvia on the most common chronic autoimmune neuropathies and evaluate SARS-CoV-2 infections or vaccinations’ impact on our patient’s clinical course of the disease.


A single-center observational study was performed, which included all patients diagnosed with chronic inflammatory demyelinating polyneuropathy (CIDP) and multifocal motor neuropathy (MMN) in Latvia since 2015. Prevalence and incidence were calculated by using population data from the corresponding time of the Central Statistics Bureau of Latvia. Detailed clinical evaluation and re-assessment of diagnostic criteria were performed in the whole study group. All patients underwent telephone interviews regarding their SARS-CoV-2 vaccination or infection status.


This study included 23 CIDP and 8 MMN patients. The point prevalence and incidence of CIDP were 1.21 per 100 000 people and 1.16 per 100 000 people, respectively. The point prevalence and incidence of MMN were 0.42 per 100 000 individuals and 0.40 per 100 000 individuals, respectively. Most of the patients involved in this study (90%, n=28) with CIDP or MMN were vaccinated against SARS-CoV-2 infection, and none of the patients experienced fluctuations or relapse regarding autoimmune polyneuropathy.


The incidence and prevalence of CIDP and MMN in Latvia are similar to previously reported European studies. In our study group, vaccination against SARS-CoV-2 was safe and did not negatively affect the clinical course of CIDP and MMN patients.

Keywords: Autoimmune neuropathies, Chronic inflammatory demyelinating polyradiculoneuropathy, Multifocal motor neuropathy, Epidemiology, SARS-CoV-2, Vaccination.