Nationwide Incidence of Normal Pressure Hydrocephalus (NPH) Assessed by Insurance Claim Data in Germany



Johannes Lemcke1, *, Dirk Stengel2, 3, Florian Stockhammer4, Claas Güthoff2, Veit Rohde4, Ullrich Meier1
1 Department of Neurosurgery, Unfallkrankenhaus Berlin, Germany
2 Center for Clinical Research, Department of Trauma and Orthopedic Surgery, Unfallkrankenhaus Berlin, Germany
3 Julius Wolff Institute, Charité Medical University Center, Berlin, Germany
4 Department of Neurosurgery, Georg August University of Göttingen, Germany


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© Lemcke et al.; Licensee Bentham Open.

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution-Non-Commercial 4.0 International Public License (CC BY-NC 4.0) (https://creativecommons.org/licenses/by-nc/4.0/legalcode), which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

* Address correspondence to this author at the Department of Neurosurgery, Unfallkrankenhaus Berlin, Warener Str. 7, 12683 Berlin, Germany; Tel: ++49 30 5681 37016; Fax: ++49 30 5681 3703; E-mails: johannes.lemcke@ukb.de, johannes.lemcke@web.de


Abstract

Background:

The purpose of this study is to investigate the epidemiology of the idiopathic normal pressure hydrocephalus (iNPH) in Germany.

Methods:

The database of the nationwide Barmer Health Insurance was queried for specific combinations of corresponding International Classification of Diseases, Ninth Revision (ICD-9) codes and OPS codes (German modification of the ICPM and official classification of surgical procedures) in order to assess the number of patients treated for iNPH and the number surgical procedures associated with the disease in a 10 years period between 2003 and 2012.

Results:

Between 2003 and 2012, the incidence of iNPH increased from zero to 1.36/100.000/year.

Conclusion:

This is the first population-based epidemiologic study on iNPH in Germany covering a ten year period.

Keywords: Epidemiology, Incidence, Normal pressure hydrocephalus, Shunt surgery.



INTRODUCTION

Idiopathic Normal Pressure Hydrocephalus (iNPH) remains the currently only curable form of dementia. The treatment of choice is surgical drainage by ventriculo-peritoneal shunting. Previous pathophysiological concepts explaining iNPH as a mismatch between production and resorption of cerebrospinal fluid (CSF) were recently challenged by the vascular sclerosis theory [1, 2]. Sclerotic vessels cannot transform pulsatile into laminar blood flows. Thus, unabated intracranial systolic peaks may press the periventricular brain to the ventricular volume and subsequently cause mechanical damage of ependymal cells.

Better understanding of the pathophysiology of iNPH together with advances in brain imaging prompted interest in this condition by health care providers and policy makers. The epidemiology of iNPH in the industrialized countries, specifically the prevalence of the disease among all forms of dementia, is, however, difficult to estimate. Data from Vestfold County in Norway with a stable population of 220000 inhabitants suggest a prevalence of probable iNPH of 21.9 and an incidence of 5.5 per 100,000 [2], with up to 1.5 / 100,000 patients undergoing surgery annually [3].

In Germany, researchers interested in the epidemiology of iNPH often refer to data from the cross-sectional Starnberg study, a door-to-door survey conducted in two rural villages in the Isar valley in Bavaria, Southern Germany, almost two decades ago. The study was originally intended to study Parkinsonism, not iNPH, and may thus suffer from substantial misclassification bias [4]. The researchers claimed a prevalence of iNPH-related gait disorders of 4 / 982 (0.41%). This estimate is not representative for the German population either.

Compulsory health insurance in Germany is covered by various insurance bodies and companies. The Barmer GEK is one of the largest statutory insurance companies and provides health insurance for 8.7 million people (about 10% of the entire German population, see http://www.barmer-gek.de). German data safety and protection rules are very strict and limit research activities based on routine administrative hospital and discharge information.

Yet, Barmer granted these researchers access to anonymized datasets to answer the following key questions

  1. What is the prevalence of iNPH amongst all (Barmer-insured) subjects with signs and symptoms of dementia?
  2. What is the annual incidence (n/100,000) of iNPH in Barmer-insured subjects and Barmer-insured subjects with newly diagnosed dementia?

MATERIAL AND METHODS

Data Source

Barmer allowed the investigators to search several combinations of hospital diagnoses according to ICD-9 (International Classification of Diseases, Ninth Revision) and OPS codes (German modification of the International Classification of Procedures in Medicine [ICPM], and official classification of surgical procedures). Due to legal restrictions, any data allowing for identifying individual patients, medical institutions or physicians in any form were kept anonymous. The number of individuals insured by Barmer between 2003 and 2012 ranged from 6.8 to 8.7 million. Cumulative data from all Barmer-covered subjects discharged from hospital care between 2003 and 2012 were included in the study.

Fig. (1).

The line represents the number of (i) NPH patients who underwent shunt surgery among the BARMER GEK insurants between 2003 and 2012, representing the incidence of NPH.


Fig. (2).

The line represents the frequency of coded NPH among the Barmer insurants between 2003 and 2012, representing the prevalence of NPH.


Fig. (3).

Frequency of ETVs in the BARMER population between 2003 and 2012.


Query Logic

Based on literature data and own experience and expertise, the authors developed a query logic using seventeen ICD-9 and OPS item combinations to trace iNPH cases (or insured subjects with a high probability of iNPH). Table 1 summarizes the query steps.

Table 1.

Translation of the epidemiological questions into a query logic of operations of ICD and OPS codes.


No. Epidemiological Question Query logic using a logic operation of German-ICD-9 codes and German OPS codes
Q1 How many patients with any type of hydrocephalus underwent surgery in that year? a) G91* AND 5-023.00; b) G91* AND 5-023.10
Q2 How many patients with (idiopathic) normal pressure hydrocephalus underwent surgery in that year? a) G91.2* AND (5-023.00 OR  5-023.10)
b) G91.20 AND (5-023.00 OR  5-023.10)
Q3 How many patients with normal pressure hydrocephalus underwent revision surgery in that year? a) G91.2* AND 5-023.00 AND 5-024*
b) G91.2* AND 5-023.10 AND 5-024*
Q4 How many patients with normal pressure hydrocephalus underwent revision surgery in that year, but had undergone shunt implantation in another, earlier year? G91.2* AND 5-024* NOT (5-023.00 OR 5-023.10)
Q5 How many patients with normal pressure hydrocephalus underwent revision surgery in that year due to infectious complications? a) G91.2* AND 5-023.00 AND 5-024* AND (G00* OR G01* OR G02* OR G03* OR G04* OR G05* OR G06* OR G07* OR G08*)
b) G91.2* AND 5-023.10 AND 5-024* AND (G00* OR G01* OR G02* OR G03* OR G04* OR G05* OR G06* OR G07* OR G08*)
Q6 cross-check: How many patients with normal pressure hydrocephalus underwent revision surgery within that year due to infectious complications? a) G91.2* AND 5-023.00 AND 5-024* AND T85.72
b) G91.2* AND 5-023.10 AND 5-024* AND T85.72
Q7 2nd cross-check: How many patients with normal pressure hydrocephalus underwent revision surgery within that year due to infectious complications? a) G91.2* AND 5-023.00 AND 5-024* AND G04.9
b) G91.2* AND 5-023.10 AND 5-024* AND G04.9
Q8 How many patients with normal pressure hydrocephalus underwent revision surgery in that year due to mechanical complications? a) G91.2* AND 5-023.00 AND 5-024* AND T85.0
b) G91.2* AND 5-023.10 AND 5-024* AND T85.0
Q9 How many NPH patients underwent surgery due to over-drainage complications? a) G91.2* AND 5-023.00 AND 5-024* AND T85.0 AND G97.2
b) G91.2* AND 5-023.10 AND 5-024* AND T85.0 AND G97.2
Q10 How many patients with iNPH underwent ICP measurement within a diagnostic pathway? 5-029.10 AND G91.20
Q11 How many patients with iNPH underwent ICP measurement within a diagnostic pathway and underwent surgery? 5-029.10 AND c AND 5-023.10
Q12 How many patients with iNPH were coded? G91.20
Q13 How many patients were coded with iNPH and Parkinson's disease? G91.20 AND G20*
Q14 How many patients were coded with iNPH and Alzheimer's disease? G91.20 AND G30*
Q15 How many patients with iNPH and Parkinson's disease underwent vp shunt surgery? G91.20 AND G20* AND 5-023.10
Q16 How many patients with iNPH and Alzheimer's disease underwent vp shunt surgery? G91.20 AND G30* AND 5-023.10
Q17 How many patients hydrocephalus underwent endoscopic IIIrd venrticulostomy? G91* AND 5-022.20

The number of patients meeting the combinations of criteria of the queries Q1 to Q18 were calculated as follows:

Q1 Incidence of Hydrocephalus in Germany

To calculate the incidence of manifest hydrocephalic diseases in Germany, the number of patients with shunt implantations within the Barmer insurants population was established by a combination of the ICD code G91* (any hydrocephalus) and the OPS code for shunt implantation (ventriculo-atrial [va] shunt 5-023.00, ventriculo-peritoneal [vp] shunt 5-023.10). The incidence was calculated with the absolute number of events and the total number of insurants belonging to the Barmer health insurance company. Knowing the incidence and number of German inhabitants, we estimated the annual number of va and vp shunt implantations for any cause in Germany.

Q2 Incidence of Normal Pressure Hydrocephalus and Idiopathic Normal Pressure Hydrocephalus in Germany

The incidence of (i)NPH was estimated by combining the diagnoses NPH (ICD G91.2*) or iNPH (ICD G91.20) with shunt surgery, i.e. vp shunt surgery (OPS 5-023.10) OR va shunt surgery (OPS 5-023.00).

Q3, Q4 Complications and revision surgery in patients with NPH

The number of patients who underwent revision surgery was queried by the combination of the ICD code for iNPH (G91.20) and the OPS codes for shunt implantation and shunt revision (5-023.00 resp. 5-023.10 AND 5-024*). The query was split into a) va shunts and b) vp shunts. Q4 traced revision operations that were performed in the year following initial shunt surgery, thus representing late complications.

Q5, Q6, Q7 Infectious complications in patients with NPH

We employed the codes for iNPH (G91.20), shunt implantation (5-023.00 resp. 5-023.10), shunt revisions (5-024.*) and infections (G00.* - G08.*) to derive the number of shunt revisions due to infectious complications. The results were cross-checked using other code combinations (Table 1).

Q8, Q9 Mechanical complications and over-drainage in patients with NPH

Mechanical complications were queried by the OPS for any mechanical dysfunction of hydrocephalus shunt valves (T85.0). To calculate the incidence of patients with over-drainage complications, the ICD code G97.2 was added.

Q10, Q11 Diagnostics

Q10 determined the frequency of ICP measurement for NPH diagnostics. Q11 targeted the number of patients who underwent surgery after being diagnosed with NPH by ICP measurement.

Q12 Prevalence of NPH in Germany

The prevalence of NPH independently of a procedure was ascertained by the G91.20 code.

Q13, Q14, Q15, Q16 Comorbidity

Co-morbidities were evaluated using a combined query for patients who were simultaneously coded with NPH and Alzheimer's disease (Q13) or Parkinson´s disease (Q14). Q15 and Q16 assessed co-morbidity in patients who underwent vp shunt surgery.

Q18 Endoscopic third ventriculostomy (ETV)

Q18 was used to calculate the frequency of ETV procedures for any kind of hydrocephalus.

Statistical Analysis

The prevalence and incidence of iNPH were reported as n/100,000 inhabitants. Since the number of Barmer insurants represent almost one tenth of German population, epidemiological estimates were regarded representative for the entire nation.

This study was exploratory, and no inferential statistics were applied. Presuming a Poisson distribution, 95% confidence intervals (CI) were calculated for all rate and ratio estimates. STATA 11.2 software was used for all descriptive analyses.

RESULTS

Incidence

The results of invidual queries are shown in Tables 2-8.

Table 2.

Absolute numbers of va and vp shunts implanted for any indication a) in the insurants of the BARMER GEK health insurance company; b) estimation of total numbers of va and vp shunt operations for Germany; c) calculated incidence of va and vp shunt operations due to any indication per 100.000 inhabitants per year for Germany.


Year a) BARMER GEK health insurance b) Estimation for Germany c) Incidence (per 100.000 inhabitants per year in Germany) with 95% confidence intervals
insurants (total) va shunt (Q1a) vp shunt (Q1b) Total inhabitants Germany va shunt vp shunt va shunt vp shunt
2003 7,478,603 28 300 80,493,000 301 3229 0.37 (0.25; 0.54) 4.01 (3.57; 4.49)
2004 7,259,609 33 398 81,844,000 372 4487 0.45 (0.32; 0.64) 5.48 (4.96; 6.05)
2005 7,096,165 50 474 81,752,000 576 5461 0.70 (0.52; 0.93) 6.68 (6.09; 7.31)
2006 6,961,988 35 487 81,802,000 411 5722 0.50 (0.35; 0.7) 7.00 (6.39; 7.64)
2007 6,883,815 30 529 82,002,000 357 6302 0.44 (0.29; 0.62) 7.68 (7.04; 8.37)
2008 6,809,292 20 537 82,218,000 241 6484 0.29 (0.18; 0.45) 7.89 (7.23; 8.58)
2009 6,780,370 23 555 82,315,000 279 6738 0.34 (0.22; 0.51) 8.19 (7.52; 8.9)
2010 8,531,738 21 542 82,438,000 203 5237 0.25 (0.15; 0.38) 6.35 (5.83; 6.91)
2011 8,615,687 26 490 82,501,000 249 4692 0.30 (0.2; 0.44) 5.69 (5.19; 6.21)
2012 8,658,107 34 556 82,532,000 324 5300 0.39 (0.27; 0.55) 6.42 (5.9; 6.98)

Altogether, the annual incidence of hydrocephalus treated by shunt surgery was estimated at 6.94 / 100,000 (Table 2). The estimated incidence of iNPH treated by shunt surgery was 1.08 / 100,000 (Table 3, Fig. 1).

Table 3.

Total numbers of Barmer patients who underwent shunt surgery for NPH resp. iNPH, calculated incidence and estimated total number for Germany.


Year NPH iNPH
nBARMER incidence nGermany nBARMER incidence nGermany
2003 64 0,86 689 0 0,00 0
2004 70 0,96 789 31 0,43 349
2005 115 1,62 1325 64 0,90 737
2006 141 2,03 1657 86 1,24 1010
2007 141 2,05 1680 101 1,47 1203
2008 121 1,78 1461 78 1,15 942
2009 167 2,46 2027 109 1,61 1323
2010 163 1,91 1575 117 1,37 1131
2011 144 1,67 1379 110 1,28 1053
2012 165 1,91 1573 118 1,36 1125
mean 129 1,73 1416 81 1,08 887

Prevalence

According to the Barmer data we estimated total numbers of patients with iNPH in Germany between 8609 and 11363 for the last 5 years of the sample period (2008-2012) (Table 7, Fig. 2).

Revision Surgery

We found a mean incidence of 0.19 / 100,000 of shunt revision surgery within one year after the initial shunt implantation (Table 4). This corresponds to the incidence of early shunt complications. Given the incidence of shunt implantations due to NPH of 1.73 / 100,000, this means a 10% revision rate in the first year. The reasons for these revisions also include mechanical and infectious complications.

Table 4.

Patients with NPH undergoing revision surgery within the year of implantation, reported for Q3a) va and Q3b) vp shunts and patients with NPH undergoing revision surgery in another year than in the year of implantation independent of the shunt type (Q4).


Year How many patients with normal pressure hydrocephalus underwent revision surgery in that year? How many patients with NPH underwent revision surgery in that year but had undergone shunt implantation in another, earlier year?
Q3a (va shunts) Q3b (vp shunts) Q4 (va + vp shunts)
nBARMER incidence nGermany nBARMER incidence nGermany nBARMER incidence nGermany
2003 0 0,00 0 6 0,08 65 9 0,12 97
2004 0 0,00 0 4 0,06 45 11 0,15 124
2005 3 0,04 35 16 0,23 184 17 0,24 196
2006 4 0,06 47 19 0,27 223 16 0,23 188
2007 1 0,01 12 11 0,16 131 30 0,44 357
2008 1 0,01 12 17 0,25 205 25 0,37 302
2009 1 0,01 12 15 0,22 182 27 0,40 328
2010 1 0,01 10 20 0,23 193 24 0,28 232
2011 1 0,01 10 18 0,21 172 31 0,36 297
2012 1 0,01 10 15 0,17 143 21 0,24 200
mean 1 0,02 15 14 0,19 154 21 0,28 232

Complications

Among the annual mean number of 129 NPH patients in the Barmer population undergoing surgery, the mean number of infectious complications according to different definitions ranged from 0 to 1 per year (Table 5). Also, the frequency of reported over-drainage events was extremely low, suggesting some underreporting. It is likely that shunt infections and mechanical complications were frequently not coded correctly since only the general OPS code for shunt revision is relevant for reimbursement under German Diagnosis Related Group (DRG) conditions (Tables 5, 6).

Table 5.

Shunt revision due to infectious complications. nB number of patients within the BARMER population, inc. incidence, nG estimated number of patients in Germany.


Q5a Q5b Q6a Q6b Q7a Q7b
Year nB inc. nG nB inc. nG nB inc. nG nB inc. nG nB inc. nG nB inc. nG
2003 0 0,00 0 0 0,00 0 0 0,00 0 0 0,00 0 0 0,00 0 0 0,00 0
2004 0 0,00 0 0 0,00 0 0 0,00 0 0 0,00 0 0 0,00 0 0 0,00 0
2005 0 0,00 0 1 0,01 12 0 0,00 0 0 0,00 0 0 0,00 0 0 0,00 0
2006 2 0,03 23 1 0,01 12 0 0,00 0 0 0,00 0 1 0,01 12 0 0,00 0
2007 0 0,00 0 0 0,00 0 0 0,00 0 0 0,00 0 0 0,00 0 0 0,00 0
2008 0 0,00 0 1 0,01 12 0 0,00 0 0 0,00 0 0 0,00 0 0 0,00 0
2009 1 0,01 12 0 0,00 0 0 0,00 0 0 0,00 0 1 0,01 12 0 0,00 0
2010 0 0,00 0 3 0,04 29 0 0,00 0 0 0,00 0 0 0,00 0 0 0,00 0
2011 1 0,01 10 1 0,01 10 0 0,00 0 0 0,00 0 0 0,00 0 0 0,00 0
2012 0 0,00 0 2 0,02 19 0 0,00 0 1 0,01 12 0 0,00 0 1 0,01 12
mean 0,4 0,01 5 0,9 0,01 9 0 0,00 0 0,1 0,00 1 0,2 0,00 2 0,1 0,00 1
Table 6.

Frequencies of mechanical complications in NPH patients as coded for the Barmer population.


Q8a Q8b Q9a Q9b
Year nB inc. nG nB inc. nG nB inc. nG nB inc. nG
2003 0 0,00 0 3 0,04 32 0 0,00 0 0 0,00 0
2004 0 0,00 0 1 0,01 11 0 0,00 0 0 0,00 0
2005 2 0,03 23 5 0,07 58 0 0,00 0 0 0,00 0
2006 1 0,01 12 10 0,14 117 0 0,00 0 0 0,00 0
2007 0 0,00 0 5 0,07 60 0 0,00 0 1 0,01 12
2008 0 0,00 0 8 0,12 97 0 0,00 0 1 0,01 12
2009 0 0,00 0 5 0,07 61 0 0,00 0 0 0,00 0
2010 1 0,01 10 10 0,12 97 0 0,00 0 0 0,00 0
2011 0 0,00 0 8 0,09 77 0 0,00 0 0 0,00 0
2012 1 0,01 10 7 0,08 67 0 0,00 0 0 0,00 0
mean 0,5 0,01 5 6,2 0,08 68 0 0,00 0 0,2 0,00 2

Endoscopic Third Ventriculostomy (ETV)

The mean annual number of ETV procedures for all types of hydrocephalus ranged from 51 to 487 during the 10-year observational period (Fig. 3).

DISCUSSION

This study is the first nationwide, population-based investigation on the epidemiology of idiopathic normal pressure hydrocephalus (iNPH) in Germany. It is based on a representative sample of 7.5 million patients covered by the Barmer health insurance company. The incidence of iNPH calculated in this study resembled to that reported in ten previous investigations. These studies included between 233 and 4.6 million subjects and suggested annual incidence rates between 1.09 and 5.5 / 100,000.

The key problem in estimating the incidence of iNPH on a population-based level is the lack of accepted and accurate diagnostic test criteria, introducing misclassification bias. The aggregated sample employed in this analysis comprised 1) patients meeting clinical criteria, 2) patients who underwent invasive diagnostics, 3) patients who underwent shunt surgery, 4) patients who became shunt responders after surgery and 4) patients with unspecific coding (e.g., G91.9 for NPH rather than G91.2 for iNPH).

The cohort investigated here resembles a population that may have included a large number of false positives and may have excluded false negatives. Different definitions of iNPH are a likely source for the variation in incidence rates as shown in different studies (Table 9).

The low incidence of infectious and mechanical complications observed in this study differs markedly from literature estimates which range from 3 to 12% (4;14-17). We recently found over-drainage rates of 30% with conventional programmable valves in a randomised multicentre study (6).

Available prevalence data were often derived from selected populations such as inhabitants of nursing homes and are therefore not comparable to the present results.

Also, the risk of selection bias may be higher in smaller populations, we could not substantiate a correlation between the reported prevalence data and the population size of the studies (Table 8). So, the prevalence reported by the different authors seems to be not very stable.

Our findings suggest a 10times higher rate of ETV in all hydrocephalus cases compared to iNPH. This is in contrast to another recent population-based study on 12,845 and 652 (20:1) discharges after ETV and VPS recorded between 2007 and 2010 (18).

Table 7.

Prevalence of NPH.


Year Insurants (total) Inhabitants Germany nBARMER Prevalence (95% CI's) nGermany
2003 7.478.603 80.493.000 0 0,00% 0
2004 7.259.609 81.844.000 368 0,01% 4148
2005 7.096.165 81.752.000 477 0,01% 5495
2006 6.961.988 81.802.000 569 0,01% 6685
2007 6.883.815 82.002.000 703 0,01% 8374
2008 6.809.292 82.218.000 733 0,01% 8851
2009 6.780.370 82.315.000 936 0,01% 11363
2010 8.531.738 82.438.000 961 0,01% 9286
2011 8.615.687 82.501.000 899 0,01% 8609
2012 8.658.107 82.532.000 1000 0,01% 9532
Table 8.

Frequency of co-morbidities (Alzheimer's disease Q13 and Parkinson´s disease Q14) coded together with NPH and frequency of these co-morbidities among shunted patients (Q15, Q16).


Q13 Q14 Q15 Q16
Year nB inc. nG nB inc. nG nB inc. nG nB inc. nG
2003 0 0,00 0 0 0,00 0 0 0,00 0 0 0,00 0
2004 1 0,01 11 0 0,00 0 1 0,01 11 0 0,00 0
2005 4 0,06 46 1 0,01 12 4 0,06 46 1 0,01 12
2006 11 0,16 129 1 0,01 12 6 0,09 70 1 0,01 12
2007 9 0,13 107 1 0,01 12 7 0,10 83 1 0,01 12
2008 5 0,07 60 1 0,01 12 4 0,06 48 1 0,01 12
2009 9 0,13 109 2 0,03 24 8 0,12 97 2 0,03 24
2010 8 0,09 77 4 0,05 39 5 0,06 48 3 0,04 29
2011 7 0,08 67 0 0,00 0 5 0,06 48 0 0,00 0
2012 6 0,07 57 1 0,01 10 5 0,06 48 1 0,01 10
Table 9.

Compilation of all reported epidemiological data concerning the prevalence and incidence of iNPH in the literature [3-13].


Author Year of publication Population (n) / setting Study design Epidemiological data
Lemcke, Stockhammer, Stengl, Rohde, Meier 2016 7.507.537 (±784.241) insurants of the Bamer health insurance company Retrospective query of diagnosis and procedural coding Incidence 2012:
1.36/100.000/year
Jaraj et al. 2014 1238 patients > 70 years between 1986 and 2000 Prospective trial with CT scan and neuropsychological examnination prevalence of probable iNPH in patients between 70-79 years 0.2%, >80 years 5.9%
Muangpaisan et al. 2012 233 patients of the outpatient geriatric clinic at Siriraj Hospital, Bangkok, Thailand Retrospective query of medical records Prevalance 0.9%
Klassen and Ahlskog 2011 124,277 inhabitants of Ol-
msted County, Minnesota, USA
Retrospective query of medical records Incidence 1.19/100,000/year
Cabral et al. 2011 563 cases with neuropathology of dementia
illness at autopsy in the Sun Health Research Institute Brain Donation Program database,
The Cleo Roberts Center for Clinical Research, Banner-Sun Health Research
Institute, Sun City, AZ, USA
Retrospective query of medical records Prevalence 1.6%
(of patients with dementia)
Brean, Eide et al. 2009 4,644,761 inhabitants of Norway (2006) Retrospective query of medical records 1.09/100,000/year
(> 65 yrs. 30.2⁄00,000/year)
Tanaka et al. 2009 567 randomly selected patients out of  1,654 inhabitants of Tajiri,
Japan ≥ 65 years (Osaki-Tajiri project)
Retrospective query of medical records Prevalence of possible iNPH in patients ≥ 65 years 1.4%
Brean and Eide 2008 220,000 inhabitants of the south-eastern part of Norway Prospective population based study Incidence 5.5/100,000/year
Hiraoka et al. 2008 170 randomly selected residents over 65 years out of 2516 elderly inhabitants of the town Tajiri (Miyagi, Japan) Retrospective query of medical records Prevalence 2.9% patients ≥ 65 yrs.
Marmarou et al. 2007 147 patient  in a retrospective chart analysis using the medical records
from four nursing homes
Retrospective query of medical records Prevalence 9 to 14% (depending on the diagnostic criteria) of the inhabitants of the nursing homes
Tisell et al. 2005 891 patients who underwent surgery for hydrocephalus in one the six university
hospitals in Sweden during 1996-1998
Retrospective query of medical records 1.6/100.000/year (47% of 3.4/100.000/year)
Trenkwalder 1995 982 participants of a
door-to-door survey in the Starnberg community, Bavaria, Germany
Prospective population based study Prevalence 0.41% in patients ≥ 65 yrs.

CONCLUSION

Based on the analysis of ca. 7.5 million insurants of the Barmer health insurance we estimated an incidence of iNPH for Germany of 1.08 / 100,000 / year.

CONFLICT OF INTEREST

The authors declare that they have no competing interests.

ACKNOWLEDGEMENTS

Data from the Barmer health insurance company provided by the Barmer Berlin / Brandenburg bureau form the basis of this study. We like to thank the bureau for allowing us access to these data. However, the interpretation and conclusions presented in this manuscript do not necessarily represent the views of Barmer.

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