Simultaneous Onset of Alzheimer’s Disease in a Husband and Wife in Their Mid-Fifties: What Do We Really Know About Environmental Factors?

Pelcovits, Ari; Marriotti, Rachel; Heath, Jonathan; Perry , George; Castellani, Rudy J

Simultaneous Onset of Alzheimer’s Disease in a Husband and Wife in Their Mid-Fifties: What Do We Really Know About Environmental Factors?

Ari Pelcovits, Rachel Marriotti, Jonathan Heath, George Perry , Rudy J Castellani^*

Division of Neuropathology, 22 South Greene Street, Baltimore, MD 21201

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Identifiers and Pagination:

Year: 2015
Volume: 9
First Page: 1
Last Page: 3
Publisher ID: TONEUJ-9-1
DOI: 10.2174/1874205X01509010001

Article History:

Received Date: 10/1/2014
Revision Received Date: 24/3/2014
Acceptance Date: 25/3/2014
Electronic publication date: 31 /3/2015
Collection year: 2015

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© Pelcovits et al.; Licensee Bentham Open.

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

^* Address correspondence to this author at the Division of Neuropathology, 22 South Greene Street, Baltimore, MD 21201; Tel: 410-328-5508; Fax: 410-328-55055; E-mail: rcastellani@som.umaryland.edu

Introduction:

Environmental factors can play a role in the pathogenesis of Alzheimer’s disease. We present a case of the simultaneous onset of Alzheimer’s disease in two middle aged adults.

Case presentation:

A married couple ages 54 year and 51-year-old female cohabiting together were diagnosed with Alzheimer’s disease within the same year. The patient’s both developed cognitive decline shortly after a major renovation of their property and followed a similar disease course. The diagnosis was supported by clinical presentation and tissue pathology on autopsy.

Conclusion:

Environmental factors may play a role in the pathogenesis of Alzheimer’s disease. Further understanding of the disease cascade is required.

Keywords: Alzheimer’s, Amyloid Beta, Dementia, Environmental Toxins, Neurofibrillary Tangles, Neuropathology.

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RESEARCH ARTICLE

Simultaneous Onset of Alzheimer’s Disease in a Husband and Wife in Their Mid-Fifties: What Do We Really Know About Environmental Factors?

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