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Simultaneous Onset of Alzheimer’s Disease in a Husband and Wife in Their Mid-Fifties: What Do We Really Know About Environmental Factors?
Ari Pelcovits
Rachel Marriotti
Jonathan Heath
George Perry
Rudy J Castellani, *
Authors Info & Affiliations
Authors Info & Affiliations
Abstract
Introduction:
Environmental factors can play a role in the pathogenesis of Alzheimer’s disease. We present a case of the simultaneous onset of Alzheimer’s disease in two middle aged adults.
Case presentation:
A married couple ages 54 year and 51-year-old female cohabiting together were diagnosed with Alzheimer’s disease within the same year. The patient’s both developed cognitive decline shortly after a major renovation of their property and followed a similar disease course. The diagnosis was supported by clinical presentation and tissue pathology on autopsy.
Conclusion:
Environmental factors may play a role in the pathogenesis of Alzheimer’s disease. Further understanding of the disease cascade is required.
Keywords: Alzheimer’s, Amyloid Beta, Dementia, Environmental Toxins, Neurofibrillary Tangles, Neuropathology.
