RESEARCH ARTICLE
Neurofilamentopathy in Neurodegenerative Diseases
Quan Liu1, Fang Xie2, Abdiel Alvarado-Diaz3, Mark A Smith4, Paula I Moreira5, Xiongwei Zhu4, George Perry*, 6
Article Information
Identifiers and Pagination:
Year: 2011Volume: 5
First Page: 58
Last Page: 62
Publisher ID: TONEUJ-5-58
DOI: 10.2174/1874205X01105010058
Article History:
Received Date: 12/6/2011Revision Received Date: 25/7/2011
Acceptance Date: 28/7/2011
Electronic publication date: 26/8/2011
Collection year: 2011

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
Abstract
Neurofilament protein alterations are found in many neurodegenerative diseases, such as amyotrophic lateral sclerosis, Parkinson, Alzheimer, and Charcot-Marie-Tooth. Abnormal modifications of neurofilament, such as mutation, oxidation and phosphorylation, are linked to the disease-related alteration. In this review, the most recent discovery and central arguments about functions, pathological modifications, and genetic mutations related to neurofilaments in neurodegenerative diseases is presented.