Neurofilamentopathy in Neurodegenerative Diseases



Quan Liu1, Fang Xie2, Abdiel Alvarado-Diaz3, Mark A Smith4, Paula I Moreira5, Xiongwei Zhu4, George Perry*, 6
1 School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA
2 Department of Neuroscience, School of Medicine, UCSD, La Jolla, CA, USA
3 Department of Biological Sciences, Universidad Autonoma de Nuevo Leon, Nuevo Leon, Mexico
4 Department of Pathology, Case Western Reserve University, Cleveland, OH, USA
5 Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal
6 College of Sciences, University of Texas at San Antonio, San Antonio, TX, USA


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© Liu et al.; Licensee Bentham Open.

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

* Address correspondence to this author at the University of Texas at San Antonio, One UTSA Circle, San Antonio, Texas 78249, USA; Tel: 210-458-4450; Fax: 210-458-4445; E-mail: george.perry@utsa.edu


Abstract

Neurofilament protein alterations are found in many neurodegenerative diseases, such as amyotrophic lateral sclerosis, Parkinson, Alzheimer, and Charcot-Marie-Tooth. Abnormal modifications of neurofilament, such as mutation, oxidation and phosphorylation, are linked to the disease-related alteration. In this review, the most recent discovery and central arguments about functions, pathological modifications, and genetic mutations related to neurofilaments in neurodegenerative diseases is presented.

Keywords: Neurofilament, Alzheimer disease, Parkinson disease, Amyotrophic lateral sclerosis, Phosphorylation, Oxidation, Glycosylation.