Remission of Hypnic Headache Associated with Idiopathic Cyclic Edema with the Use of Aminaphtone

José Maria Pereira de Godoy*
Department Cardiology and Cardiovascular Surgery in Medicine School São José do Rio Preto-FAMERP and CNPq (National Council for Research and Development), Brazil

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© José Maria Pereira de Godoy; Licensee Bentham Open.

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

* Address correspondence to this author at the Rua Floriano Peixoto, 2950, São José do Rio Preto, CEP: 15010-020, SP, Brazil; Tel: 551732326362; E-mail:


Headache is one of the chief complaints among patients visiting primary care physicians. The aim of the current study is to report on a case of daily intermittent headaches in a patient with idiopathic cyclic edema. Over three years the patient suffered from headaches that started and improved at specific times. They began at about 5 to 6 o’clock in the morning and spontaneously disappeared 3 to 4 hours after getting up and thus were directly associated to sleep. The patient complained of generalized edema and had weight differences of about two kilograms between 7 a.m. and 5 p.m. A hypothesis of idiopathic cyclic edema was reached and the patient was prescribed aminaphtone which cured the headaches within two days after initiating treatment.

Keywords: Intermittent headache, aminaphtone, treatment.