Unexpected Perinatal Loss versus Sids-a Common Neuropathologic Entity
Luigi Matturri1 , *, Maria Mauri1, Maria Elena Ferrero2, Anna Maria Lavezzi1
Identifiers and Pagination:Year: 2008
First Page: 45
Last Page: 50
Publisher ID: TONEUJ-2-45
Article History:Received Date: 2/5/2008
Revision Received Date: 1/7/2008
Acceptance Date: 1/7/2008
Electronic publication date: 5/9/2008
Collection year: 2008
open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestrictive non-commercial use, distribution, and reproduction in any medium, provided the work is properly cited.
Objective: To evaluate the involvement of alterations of the central autonomic nervous system, particularly of the brainstem and cerebellum, in a wide set of victims of sudden and unexplained perinatal and infant death.
Material and Methods: The study population consisted of 63 stillbirths, 28 neonatal deaths and 140 suspected SIDS. The victims were subjected to in-depth anatomopathological examination following appropriate guidelines. The protocol included, in particular, the histological evaluation on serial sections of the cardiorespiratory autonomic nervous system.
Results: A diagnosis of “unexplained death” was established for 217 of the 231 victims (59 stillbirths, 28 newborns and 130 SIDS). In a very high percentage of these deaths (84%) we observed one or more anomalies of the nuclei and/or structures of the brainstem and cerebellum related to vital functions.
Conclusion: Unexpected perinatal loss should not be regarded as a separate entity from SIDS, given the common neuropathological substrates.