Inflammasome-Mediated Inflammation in Neurodegenerative Diseases
Jun Young Park1, Yeo Wool Kang2, Won Gil Cho2, *
Identifiers and Pagination:Year: 2019
First Page: 55
Last Page: 62
Publisher Id: TONEUJ-13-55
Article History:Received Date: 14/02/2019
Revision Received Date: 19/03/2019
Acceptance Date: 20/03/2019
Electronic publication date: 17/04/2019
Collection year: 2019
open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Inflammasomes are protein platforms consisting of multiple proteins. The biological function includes the activation of caspase-1, leading to the maturation of IL-1β and IL-18. These pro-inflammatory cytokines promote fundamental inflammatory processes in numerous infectious diseases. The inflammasome-mediated inflammation has become increasingly important in central nervous system disorders. In neurodegenerative disorders, significant contributors to disease progression include neuroinflammation and inflammatory cascades initiated by the inflammasome protein complex. This review discusses the recent progress of research on inflammasome associated with neurodegenerative disorders.