Clinical Outcomes of Repeated Intraventricular Transplantation of Autologous Bone Marrow Mesenchymal Stem Cells in Chronic Haemorrhagic Stroke. A One-Year Follow Up
Asra Al Fauzi1, *, Purwati Sumorejo2, Nur Setiawan Suroto1, Muhammad Arifin Parenrengi1, Joni Wahyuhadi1, Agus Turchan1, Ferdiansyah Mahyudin2, Heri Suroto2, Fedik Abdul Rantam3, Mochammad Hasan Machfoed4, Abdul Hafid Bajamal1, Christianto Benjamin Lumenta5
Identifiers and Pagination:Year: 2017
First Page: 74
Last Page: 83
Publisher Id: TONEUJ-11-74
Article History:Received Date: 12/09/2017
Revision Received Date: 11/11/2017
Acceptance Date: 23/11/2017
Electronic publication date: 19/12/2017
Collection year: 2017
open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Stroke, one of the most devastating diseases, is a leading cause of death and disability throughout the world and is also associated with emotional and economic problems. The main goal of this study was to investigate the clinical outcome of the intraventricular transplantation of bone marrow mesenchymal stem cells (BM-MSCs) in post-haemorrhagic stroke patients.
This study was done consisting of eight patients with supratentorial haemorrhagic stroke, who had undergone 24 weeks of standard treatment of stroke with stable neurological deficits. All of the patients received stem cell transplantation intraventricularly using autologous BM-MSCs. Six months and Twelve months after stem cells treatment, the clinical outcomes were measured using the National Institute of Health Stroke Scale (NIHSS) and adverse effect also observed.
The results of this study showed improvement of NIHSS score values before and after the treatment in five patients. No adverse effects or complications were detected during the 1-year observation.
Intraventricular transplantation of BM-MSCs has shown benefits in improving the functional status of post-haemorrhagic stroke patients with no adverse effect.