No Association Between rs7077361 in ITGA8 and Parkinson’s Disease in Sweden

Ran, Caroline; Mehdi, Rawand Naiel; Fardell, Camilla; Xiang, Fengqing; Nissbrandt, Hans; Sydow, Olof; Wirdefeldt, Karin; Belin, Andrea Carmine

No Association Between rs7077361 in ITGA8 and Parkinson’s Disease in Sweden

Caroline Ran^{1, *}, Rawand Naiel Mehdi¹, Camilla Fardell², Fengqing Xiang³, Hans Nissbrandt², Olof Sydow⁴, Karin Wirdefeldt^{5, 6}, Andrea Carmine Belin¹

¹ Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden

² Department of Pharmacology, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden

³ Department of Women´s and Children´s Health, Karolinska Institutet, Stockholm, Sweden

⁴ Department of Neurology, Karolinska University Hospital Solna, Stockholm, Sweden

⁵ Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden

⁶ Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden

Article Information

Identifiers and Pagination:

Year: 2016
Volume: 10
First Page: 25
Last Page: 29
Publisher ID: TONEUJ-10-25
DOI: 10.2174/1874205X01610010025

Article History:

Received Date: 13/3/2016
Revision Received Date: 10/5/2016
Acceptance Date: 15/5/2016
Electronic publication date: 30/06/2016
Collection year: 2016

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© Ran et al.; Licensee Bentham Open.

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution-Non-Commercial 4.0 International Public License (CC BY-NC 4.0) (https://creativecommons.org/licenses/by-nc/4.0/legalcode), which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

^* Address correspondence to this author at the Department of Neuroscience, Karolinska Institutet, Retzius väg 8, B2:4, 17177 Stockholm, Sweden; Tel: +46-8-524 86648; E-mail: caroline.ran@ki.se

Background:

Integrin alpha 8 (ITGA8) encodes the alpha 8 subunit of the integrin alpha8beta1 protein and has recently been suggested as a new candidate gene for Parkinson’s disease, an age related neurodegenerative disease with unknown etiology. ITGA8 is a transmembrane protein involved in several cellular processes, such as cell adhesion, migration and cytoskeletal rearrangement.

Objective:

Screen a Swedish case control material for rs7077361, a genetic variant in ITGA8, in order to investigate its possible implication in Parkinson’s disease in Sweden.

Method:

Rs7077361 was genotyped using TaqMan quantitative Real-time PCR and tested for association using appropriate statistical methods.

Results:

We have screened 502 Swedish Parkinson patients and 599 healthy control individuals for rs7077361 in ITGA8. This genetic variant was in Hardy Weinberg equilibrium in the Swedish population. Allele and genotype frequencies were highly similar between the patients and controls and statistical testing showed that this genetic maker did not associate with Parkinson’s disease (p=0.67).

Conclusion:

Our results do not support the hypothesis of ITGA8 as a candidate gene for Parkinson’s disease in Sweden.

Keywords: Association study, ITGA8, LRRK2, Parkinson’s disease, rs7077361, SNP.

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RESEARCH ARTICLE

No Association Between rs7077361 in ITGA8 and Parkinson’s Disease in Sweden

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Abstract

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