No Association Between rs7077361 in ITGA8 and Parkinson’s Disease in Sweden



Caroline Ran1, *, Rawand Naiel Mehdi1, Camilla Fardell2, Fengqing Xiang3, Hans Nissbrandt2, Olof Sydow4, Karin Wirdefeldt5, 6, Andrea Carmine Belin1
1 Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
2 Department of Pharmacology, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
3 Department of Women´s and Children´s Health, Karolinska Institutet, Stockholm, Sweden
4 Department of Neurology, Karolinska University Hospital Solna, Stockholm, Sweden
5 Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
6 Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden


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© Ran et al.; Licensee Bentham Open.

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution-Non-Commercial 4.0 International Public License (CC BY-NC 4.0) (https://creativecommons.org/licenses/by-nc/4.0/legalcode), which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

* Address correspondence to this author at the Department of Neuroscience, Karolinska Institutet, Retzius väg 8, B2:4, 17177 Stockholm, Sweden; Tel: +46-8-524 86648; E-mail: caroline.ran@ki.se


Abstract

Background:

Integrin alpha 8 (ITGA8) encodes the alpha 8 subunit of the integrin alpha8beta1 protein and has recently been suggested as a new candidate gene for Parkinson’s disease, an age related neurodegenerative disease with unknown etiology. ITGA8 is a transmembrane protein involved in several cellular processes, such as cell adhesion, migration and cytoskeletal rearrangement.

Objective:

Screen a Swedish case control material for rs7077361, a genetic variant in ITGA8, in order to investigate its possible implication in Parkinson’s disease in Sweden.

Method:

Rs7077361 was genotyped using TaqMan quantitative Real-time PCR and tested for association using appropriate statistical methods.

Results:

We have screened 502 Swedish Parkinson patients and 599 healthy control individuals for rs7077361 in ITGA8. This genetic variant was in Hardy Weinberg equilibrium in the Swedish population. Allele and genotype frequencies were highly similar between the patients and controls and statistical testing showed that this genetic maker did not associate with Parkinson’s disease (p=0.67).

Conclusion:

Our results do not support the hypothesis of ITGA8 as a candidate gene for Parkinson’s disease in Sweden.

Keywords: Association study, ITGA8, LRRK2, Parkinson’s disease, rs7077361, SNP.