CASE REPORT
HSV-2 Induced Cerebellitis: A Case Report of HSV-2 Reactivation by SARS-CoV-2 Infection
Fahimeh Ehsanipur1, Mohammad Vafaee-Shahi2, *, Leila Tahernia3, Aina Riahi4
1 Department of Pediatric Infectious Diseases, Rasool Akram Hospital, Iran University of Medical Sciences, Tehran, Iran
2 Pediatric Growth and Development Research Center, Institute of Endocrinology and Metabolism, Iran University of Medical Sciences, Tehran, Iran
Article Information
Identifiers and Pagination:
Year: 2023Volume: 17
E-location ID: e1874205X259383
Publisher ID: e1874205X259383
DOI: 10.2174/011874205X259383231031051625
Article History:
Received Date: 18/05/2023Revision Received Date: 18/08/2023
Acceptance Date: 05/10/2023
Electronic publication date: 03/11/2023
Collection year: 2023
open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
Background:
Herpes simplex virus type 2 rarely causes encephalitis in humans. Some DNA viruses, such as HSV-1 and HSV-2, can be reactivated by COVID-19 infection. SARS-CoV-2 causes a wide spectrum of neurological deficits, such as stroke, delirium, movement disorders, and neuropathy.
Case Presentation:
An unusual manifestation of HSV-2 was diagnosed as cerebellitis in our patient. It was concluded that SARS-CoV-2 can reactivate DNA viruses, such as HSV-2. Here, we reported a 1-year-old female infant with cerebellitis due to herpes simplex virus type 2 infection.
Conclusion:
The patient was treated with intravenous acyclovir and oral prednisolone for three weeks. Finally, during her 9-month neurological follow-up, she was able to walk with minimal ataxia.
Keywords: HSV-2, COVID-19, Cerebellitis, Ataxia, Encephalitis, HSV-1.
