Chronic Pain and Levodopa Therapy in Parkinson’s Disease Patients
Carlos Henrique Ferreira Camargo1, *, Marcelo Rezende Young Blood2, Camila Medyk2, Matheus Gomes Ferreira3, Marcelo Machado Ferro4, Hélio Afonso Ghizoni Teive1, 3
Pain is a frequent non-motor symptom in patients with Parkinson’s disease (PD) and appears to be related to low levels of dopamine. This study describes the characteristics of chronic pain in a group of PD patients undergoing levodopa therapy.
This was a cross-sectional study.Pain was assessed in 21 selected PD patients with chronic pain, using several scales and instruments. Changes in pain response from levodopa use (wearing-off phenomenon) were monitored.
The most prevalent type of pain was nociceptive (71.4%), musculoskeletal and dystonic, but neuropathic pain accounted for the highest pain score according to the Parkinson’s Disease Pain Classification System (45.5±30.08). Patients with neuropathic, nociplastic, or nociceptive pain upon wearing-off were those who responded to levodopa (p=0.999). Patients with pain upon wearing-off had higher scores in the affective/motivational dimension according to the McGill questionnaire (p=0.022).
Using a new pain classification and scoring tool, this study corroborates a good response to levodopa in PD-related pain.
* Address correspondence to this author at the Hospital de Clínicas, Programa de Pós-Graduação em Medicina Interna – 11º Andar, Rua General Carneiro, 181, 80060-000, Curitiba, PR, Brazil email@example.com